Apolipoprotein B Recombinant Rabbit mAb - diagbio | 戴格生物

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Apolipoprotein B Recombinant Rabbit mAb

db14604

Product Name : Apolipoprotein B Recombinant Rabbit mAb

Cat.No.: db14604

Synonyms : FLDB; LDLCQ4; apoB-48; apoB-100

Application : WB, FC, IP

Reactivity : Human

Host species : Rabbit

Background This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human Apolipoprotein B
Gene ID 338
Swiss Prot P04114
Synonyms FLDB; LDLCQ4; apoB-48; apoB-100
Reactivity Human
Application WB, FC, IP
Recommended dilution WB: 1:2000-1:10000
FC: 1:200
IP: 1:20
Calculated MW 516 kDa
Observed MW 516 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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