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Phospho-Amyloid Precursor Protein (Thr743) Recombinant Rabbit mAb
db14545
Datasheet
- Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr743 of human Amyloid Precursor Protein
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Gene ID
351
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Swiss Prot
P05067
- Synonyms AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma
- Reactivity Human,Mouse,Rat
- Application WB, ICC/IF, IP
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Recommended dilution
WB: 1:1000
ICC/IF: 1:100
IP: 1:50 - Calculated MW 87 kDa
- Observed MW 100 kDa
- Host species Rabbit
- Clonality Monoclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Amyloid Precursor Protein (phospho-Thr743) in Hela,U2OS,C6 cell lysates using Amyloid Precursor Protein (phospho-Thr743) antibody(1:1000 diluted). -
Immunofluorescent analysis of LNCaP cells using db14545 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
