Phospho-ATP citrate lyase (Thr447/Ser451) Recombinant Rabbit mAb - diagbio

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Phospho-ATP citrate lyase (Thr447/Ser451) Recombinant Rabbit mAb

db14234

Product Name : Phospho-ATP citrate lyase (Thr447/Ser451) Recombinant Rabbit mAb

Cat.No.: db14234

Synonyms : ACL; ATPCL; CLATP

Application : WB, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr447/Ser451 of human ATP citrate lyase
Gene ID 47
Swiss Prot P53396
Synonyms ACL; ATPCL; CLATP
Reactivity Human, Mouse, Rat
Application WB, ICC/IF, IP
Recommended dilution WB: 1:1000
ICC/IF: 1:50
IP: 1:20
Calculated MW 121 kDa
Observed MW 121 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Phospho-ATP citrate lyase (Thr447+Ser451) in K562 cell lysates using Phospho-ATP citrate lyase (Thr447+Ser451) antibody(1:1000 diluted).

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