Phospho-AMPK alpha 1 (Ser496) Recombinant Rabbit mAb - diagbio

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Phospho-AMPK alpha 1 (Ser496) Recombinant Rabbit mAb

db14230

Product Name : Phospho-AMPK alpha 1 (Ser496) Recombinant Rabbit mAb

Cat.No.: db14230

Synonyms : AMPK; AMPKa1

Application : WB, ICC/IF, IP

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser496 of human AMPK alpha 1
Gene ID 5562
Swiss Prot Q13131
Synonyms AMPK; AMPKa1
Reactivity Human
Application WB, ICC/IF, IP
Recommended dilution WB: 1:10001:50
IP: 1:20
Calculated MW 64 kDa
Observed MW 64 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of AMPK alpha 1 (phospho-Ser496) in Ramos cell lysates using AMPK alpha 1 (phospho-Ser496) antibody(1:1000 diluted).
Western blot analysis of extracts from Hela cells using db14230 at 1:1000.

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