Phospho-MCM2 (Ser40) Recombinant Rabbit mAb - diagbio | 戴格生物

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Phospho-MCM2 (Ser40) Recombinant Rabbit mAb

db14023

Product Name : Phospho-MCM2 (Ser40) Recombinant Rabbit mAb

Cat.No.: db14023

Synonyms : BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN

Application : WB, IHC, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser40 of human MCM2
Gene ID 4171
Swiss Prot P49736
Synonyms BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN
Reactivity Human, Mouse, Rat
Application WB, IHC, IP
Recommended dilution WB: 1:1000
IHC: 1:20
IP: 1:20
Calculated MW 102 kDa
Observed MW 125 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of MCM2 (phospho-Ser40) in Hela,A549,MCF-7,293T,C2C12 cell lysates using MCM2 (phospho-Ser40) antibody(1:1000 diluted).
Western blot analysis of extracts from HCT116，A431 cells using db14023 at 1:1000.

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