BackgroundThis gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding
Ser40 of human Nrf2
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of Phospho-Nrf2 (Ser40) in K562,Hela cell lysates using Phospho-Nrf2 (Ser40) antibody(1:1000 diluted).
Western blot analysis of extracts from HCT116 cells using db14010 at 1:2000.
Immunohistochemical analysis of paraffin-embedded human tonsil using db14010 antibody.