Phospho-MLKL (Ser358) (DGR13914) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

Phospho-MLKL (Ser358) (DGR13914) Rabbit mAb

db13999

Datasheet

Product Name : Phospho-MLKL (Ser358) (DGR13914) Rabbit mAb

Cat.No.: db13999

Synonyms : hMLKL

Application : WB, IHC-P

Reactivity : Human

Host species : Rabbit

Background This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser358 of human MLKL
Gene ID 197259
Swiss Prot Q8NB16
Synonyms hMLKL
Reactivity Human
Application WB, IHC-P
Recommended dilution WB: 1:1000
IHC-P: 1:200-1:500
Calculated MW 55 kDa
Observed MW 55 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR13914
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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