Phospho-TGF beta Receptor II (Ser225) Recombinant Rabbit mAb - diagbio

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Phospho-TGF beta Receptor II (Ser225) Recombinant Rabbit mAb

db13939

Product Name : Phospho-TGF beta Receptor II (Ser225) Recombinant Rabbit mAb

Cat.No.: db13939

Synonyms : AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser225 of human TGF beta Receptor II
Gene ID 7048
Swiss Prot P37173
Synonyms AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000-1:5000
Calculated MW 65 kDa
Observed MW 85 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot analysis of extracts from Rat heart tissue using db13939 at 1:2000.

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