Phospho-eIF4EBP1/eIF4EBP2/eIF4EBP3 (Thr45) Recombinant Rabbit mAb - diagbio

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Phospho-eIF4EBP1/eIF4EBP2/eIF4EBP3 (Thr45) Recombinant Rabbit mAb

db13818

Product Name : Phospho-eIF4EBP1/eIF4EBP2/eIF4EBP3 (Thr45) Recombinant Rabbit mAb

Cat.No.: db13818

Synonyms : BP-1; 4EBP1; 4E-BP1; PHAS-I

Application : WB, IHC, ICC/IF, IP

Reactivity : Human, Mouse

Host species : Rabbit

Background This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr45 of human eIF4EBP1
Gene ID 1978
Swiss Prot Q13541
Synonyms BP-1; 4EBP1; 4E-BP1; PHAS-I
Reactivity Human, Mouse
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:2000
IHC: 1:50
ICC/IF: 1:50
IP: 1:20
Calculated MW 13 kDa
Observed MW 15-20 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Phospho-eIF4EBP1 (Thr46) in K562,C6,3T3,Hela cell lysates using Phospho-eIF4EBP1 (Thr46) antibody(1:1000 diluted).

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