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Phospho-PKC zeta/lambda (Thr410/Thr412) Recombinant Rabbit mAb
db13764
Datasheet
- Background Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr410 of human PKC zeta
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Gene ID
5582
5584
5590
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Swiss Prot
P05129
P41743
Q05513
- Synonyms PKCC; PKCG; SCA14; PKCI(3); PKCgamma; PKC-gamma
- Reactivity Human, Mouse, Rat
- Application WB, IHC
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Recommended dilution
WB: 1:1000
IHC: 1:20 - Calculated MW 68 kDa
- Observed MW 76 kDa
- Host species Rabbit
- Clonality Monoclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of PKC zeta (phospho-Thr410)/PKC lambda (phospho-Thr412) in Hela,A549,HL-60 using PKC zeta (phospho-Thr410)/PKC lambda (phospho-Thr412) antibody(1:1000 diluted)
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
