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Phospho-ERK1/2 (Thr202/Thr185) Recombinant Rabbit mAb
db13437
Datasheet
- Background This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr185 of human ERK2
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Gene ID
5594
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Swiss Prot
P28482
- Synonyms ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
- Reactivity Human, Mouse, Rat
- Application WB, IHC, ICC/IF, IP
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Recommended dilution
WB: 1:1000
IHC: 1:100
ICC/IF: 1:100-1:500
IP: 1:20 - Calculated MW 41 kDa
- Observed MW 44,42 kDa
- Host species Rabbit
- Clonality Monoclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Phospho-p44/42 MAPK (ERK1/2) (Thr202) in C6,CHO-K1 cell lysates using Phospho-p44/42 MAPK (ERK1/2) (Thr202) antibody(1:1000 diluted). -
Western blot analysis of extracts from HeLa cells using db13437 at 1:1000.
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
