BackgroundThe protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of KMT4/Dot1L in Hela,A549,HL-60 cell lysates using KMT4/Dot1L antibody(1:1000 diluted).
Immunohistochemical analysis of paraffin-embedded mouse testis using db13343 antibody.