BackgroundThe protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
ImmunogenA synthetic phosphopeptide corresponding to residues surrounding
Ser9 of human GSK3 beta
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of Phospho-GSK3 beta (Ser9) in K562,C6,3T3,Hela cell lysates using Phospho-GSK3 beta (Ser9) antibody(1:1000 diluted).
Immunohistochemical analysis of paraffin-embedded human colon cancer using db13257 antibody.
Immunofluorescent analysis of HeLa cells using db13257 antibody (green), and DAPI (blue).