Phospho-Histone H2A.X (Ser139) Recombinant Rabbit mAb - diagbio

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Phospho-Histone H2A.X (Ser139) Recombinant Rabbit mAb

db13191

Product Name : Phospho-Histone H2A.X (Ser139) Recombinant Rabbit mAb

Cat.No.: db13191

Synonyms : H2AX; H2A.X; H2A/X

Application : WB, IHC, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser139 of human gamma H2A.X
Gene ID 3014
Swiss Prot P16104
Synonyms H2AX; H2A.X; H2A/X
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:2000-1:10000
IHC: 1:200-1:1000
ICC/IF: 1:200
IP: 1:20
Calculated MW 15 kDa
Observed MW 15 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of gamma H2A.X (Phospho-Ser139) in Jurkat,THP-1,C6,3T3 cell lysates using gamma H2A.X (Phospho-Ser139) antibody(1:1000 diluted).

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