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Phospho-p130 (Thr986) Recombinant Rabbit mAb
db13112
Datasheet
- Background Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130
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Gene ID
5934
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Swiss Prot
Q08999
- Synonyms Rb2; P130
- Reactivity Human, Mouse
- Application WB, FC, IP
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Recommended dilution
WB: 1:1000
FC: 1:50
IP: 1:20 - Calculated MW 128 kDa
- Observed MW 130 kDa
- Host species Rabbit
- Clonality Monoclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Phospho-Rb2 p130 (Thr986) in K562 cell lysates using Phospho-Rb2 p130 (Thr986) antibody(1:1000 diluted). -
Western blot analysis of extracts from C2C12 cells and Mouse muscle tissue using db13112 at 1:1000.
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
