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PEN2 (DGR32344) Rabbit mAb
db12942
Datasheet
- Background Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- Immunogen A synthetic peptide of human PEN2
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Gene ID
55851
-
Swiss Prot
Q9NZ42
- Synonyms PEN2; PEN-2; MDS033; ACNINV2; MSTP064
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, FC
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Recommended dilution
WB: 1:1000-1:5000
IHC-P: 1:100-1:200
FC: 1:100-1:500 - Calculated MW 12 kDa
- Observed MW 12 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR32344
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of PEN2 in Hela,A549HL-60,C6 using PEN2 antibody(1:1000 diluted) -
Immunohistochemical analysis of paraffin-embedded human lung cancer using db12942 antibody.
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
