Glutathione Peroxidase 3/GPx-3 Recombinant Rabbit mAb
Product Name :
Glutathione Peroxidase 3/GPx-3 Recombinant Rabbit mAb
Cat.No.:
db12780
Synonyms :
GPx; EGPx; GSHPx-3; GSHPx-P; AA960521
Application :
WB, IHC-P
Reactivity :
Mouse,Rat
Host species :
Rabbit
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Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is highly expressed in mouse kidney, which appears to be the major source of the enzyme in plasma. It has a role in mouse organogenesis, and dysregulation of this isozyme has been associated with obesity-related metabolic complications, platelet-dependent thrombosis, colitis-associated carcinoma, and thermosensitive phenotype. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2016]
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Immunogen
Recombinant protein of mouse Glutathione Peroxidase 3/GPx-3
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Gene ID
14778
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Swiss Prot
P23764
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Synonyms
GPx; EGPx; GSHPx-3; GSHPx-P; AA960521
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Reactivity
Mouse,Rat
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Application
WB, IHC-P
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Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:500
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Calculated MW
25 kDa
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Observed MW
25 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from Rat kidney tissue using db12780 at 1:1000.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期:现货
For research use only. Not intended for diagnostic.