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Activin Receptor Type IIB (DGR31436) Rabbit mAb
db12436
Datasheet
- Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human Activin Receptor Type IIB/ACVR2B
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Gene ID
93
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Swiss Prot
Q13705
- Synonyms HTX4; ACTRIIB; ActR-IIB
- Reactivity Human,Mouse,Rat
- Application WB, IP
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Recommended dilution
WB: 1:1000-1:5000
IP: 1:20 - Calculated MW 58 kDa
- Observed MW 58 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR31436
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Activin Receptor Type IIB/ACVR2B in CHO-K1,mouse Brain using Activin Receptor Type IIB/ACVR2B antibody(1:1000 diluted)
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
