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Caspase-1 (DGR16419) Rabbit mAb
db12385
Datasheet
- Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
- Immunogen Recombinant protein of human Caspase-1
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Gene ID
834
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Swiss Prot
P29466
- Synonyms ICE; P45; IL1BC
- Reactivity Human
- Application WB, IP
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Recommended dilution
WB: 1:1000
IP: 1:20-1:50 - Calculated MW 45 kDa
- Observed MW 45,20 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR16419
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Caspase-1 in Hela cell lysates using Caspase-1 antibody(1:500 diluted).
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
