PUMA (DGR14872) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

PUMA (DGR14872) Rabbit mAb

db12341

Datasheet

Product Name : PUMA (DGR14872) Rabbit mAb

Cat.No.: db12341

Synonyms : JFY1; PUMA; JFY-1

Application : WB, IHC-P, ICC/IF, FC

Reactivity : Human

Host species : Rabbit

Background This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Immunogen A synthetic peptide of human PUMA
Gene ID 27113
Swiss Prot Q9BXH1
Synonyms JFY1; PUMA; JFY-1
Reactivity Human
Application WB, IHC-P, ICC/IF, FC
Recommended dilution WB: 1:1000-1:5000
IHC-P: 1:100
ICC/IF: 1:200-1:500
FC: 1:20-1:100
Calculated MW 21 kDa
Observed MW 21 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR14872
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of PUMA in Jurkat,THP-1,C6,3T3,Hela cell lysates using PUMA antibody(1:1000 diluted).
Immunohistochemical analysis of paraffin-embedded human breast cancer using db12341 antibody.
Immunofluorescent analysis of 293T cells using db12341 antibody (green), and DAPI (blue).

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