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MCM4 Recombinant Rabbit mAb
db12303
Datasheet
- Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human MCM4
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Gene ID
4173
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Swiss Prot
P33991
- Synonyms NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21
- Reactivity Human, Mouse
- Application WB, FC, IP
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Recommended dilution
WB: 1:2000-1:10000
FC: 1:20-1:100
IP: 1:20 - Calculated MW 97 kDa
- Observed MW 97 kDa
- Host species Rabbit
- Clonality Monoclonal
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of MCM4 in Hela,A549,MCF-7,U251 cell lysates using MCM4 antibody(1:1000 diluted).
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
