BackgroundEnables cytoskeletal protein binding activity; protein deacetylase activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein deacetylation; and protein destabilization. Acts upstream of or within several processes, including aggresome assembly; cellular protein metabolic process; and neuron projection morphogenesis. Located in several cellular components, including dendrite; microtubule cytoskeleton; and perikaryon. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early embryo; future midbrain; gut gland; and lung. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot analysis of extracts from Neuro-2a cells using db12281 at 1:1000.