BackgroundThis gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
ImmunogenA synthetic peptide of human Lipoamide Dehydrogenase
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of Lipoamide Dehydrogenase in K562,Rat Brain,C6,3T3,Hela cell lysates using Lipoamide Dehydrogenase antibody(1:1000 diluted).
Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using db12224 antibody.
Immunofluorescent analysis of HeLa cells using db12224 antibody (green), and DAPI (blue).