Axin 2 Recombinant Rabbit mAb - diagbio | 戴格生物

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Axin 2 Recombinant Rabbit mAb

db12143

Datasheet

Product Name : Axin 2 Recombinant Rabbit mAb

Cat.No.: db12143

Synonyms : AXIL; ODCRCS

Application : WB, IHC-P, ICC/IF

Reactivity : Human,Mouse,Rat

Host species : Rabbit

Background The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human Axin 2
Gene ID 8313
Swiss Prot Q9Y2T1
Synonyms AXIL; ODCRCS
Reactivity Human,Mouse,Rat
Application WB, IHC-P, ICC/IF
Recommended dilution WB: 1:1000
IHC-P: 1:100-1:200
ICC/IF: 1:100
Calculated MW 94 kDa
Observed MW 94 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Axin 2 in K562,C6,3T3,Hela cell lysates using Axin 2 antibody(1:1000 diluted).

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