Dnmt1 Recombinant Rabbit mAb - diagbio | 戴格生物

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Dnmt1 Recombinant Rabbit mAb

db12139

Product Name : Dnmt1 Recombinant Rabbit mAb

Cat.No.: db12139

Synonyms : AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI

Application : WB, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Immunogen A synthetic peptide of human Dnmt1
Gene ID 1786
Swiss Prot P26358
Synonyms AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI
Reactivity Human
Application WB, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
ICC/IF: 1:20
FC: 1:20-1:100
IP: 1:20
Calculated MW 183 kDa
Observed MW 183 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot analysis of extracts from Jurkat,HCT116 cells using db12139 at 1:1000.

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