CDK6 Recombinant Rabbit mAb - diagbio | 戴格生物

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CDK6 Recombinant Rabbit mAb

db12115

Product Name : CDK6 Recombinant Rabbit mAb

Cat.No.: db12115

Synonyms : MCPH12; PLSTIRE

Application : WB, IHC, ICC/IF, FC

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Immunogen A synthetic peptide of human Cdk6
Gene ID 1021
Swiss Prot Q00534
Synonyms MCPH12; PLSTIRE
Reactivity Human
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:5000-1:10000
IHC: 1:20-1:100
ICC/IF: 1:50
FC: 1:20-1:100
Calculated MW 37 kDa
Observed MW 37 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of CDK6 in K562,Hela cell lysates using CDK6 antibody(1:1000 diluted).

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