BackgroundThis gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of VDAC1 in Jurkat,Rat Brain,C6 cell lysates using VDAC1 antibody(1:1000 diluted).
Western blot analysis of extracts from HeLa cells and Mouse liver tissue using db12109 at 1:1000.
Immunohistochemical analysis of paraffin-embedded human colon cancer using db12109 antibody.