CDK4 Recombinant Rabbit mAb - diagbio | 戴格生物

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CDK4 Recombinant Rabbit mAb

db11715

Product Name : CDK4 Recombinant Rabbit mAb

Cat.No.: db11715

Synonyms : CMM3; PSK-J3

Application : WB, ICC/IF, FC, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human Cdk4
Gene ID 1019
Swiss Prot P11802
Synonyms CMM3; PSK-J3
Reactivity Human, Mouse, Rat
Application WB, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
ICC/IF: 1:50
FC: 1:20
IP: 1:20
Calculated MW 34 kDa
Observed MW 34 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Cdk4 in K562,Hela cell lysates using Cdk4 antibody(1:1000 diluted).

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