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MBD2 (DGR14399) Rabbit mAb
db11623
Datasheet
- Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Immunogen A synthetic peptide of human MBD2
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Gene ID
8932
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Swiss Prot
Q9UBB5
- Synonyms DMTase; NY-CO-41
- Reactivity Human, Mouse, Rat
- Application WB, IHC, ICC/IF, FC, IP
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Recommended dilution
WB: 1:1000
IHC: 1:20-1:500
ICC/IF: 1:100
FC: 1:20
IP: 1:20 - Calculated MW 43 kDa
- Observed MW 43 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR14399
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of MBD2 in Rat Brain,C6,3T3,Hela cell lysates using MBD2 antibody(1:1000 diluted). -
Immunohistochemical analysis of paraffin-embedded human tonsil using db11623 antibody. -
Immunofluorescent analysis of HL-60 cells using db11623 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
