MBD2 Recombinant Rabbit mAb - diagbio | 戴格生物

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MBD2 Recombinant Rabbit mAb

db11623

Product Name : MBD2 Recombinant Rabbit mAb

Cat.No.: db11623

Synonyms : DMTase; NY-CO-41

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Immunogen A synthetic peptide of human MBD2
Gene ID 8932
Swiss Prot Q9UBB5
Synonyms DMTase; NY-CO-41
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC: 1:20-1:500
ICC/IF: 1:100
FC: 1:20
IP: 1:20
Calculated MW 43 kDa
Observed MW 43 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of MBD2 in Rat Brain,C6,3T3,Hela cell lysates using MBD2 antibody(1:1000 diluted).

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