BackgroundThe protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of NUMB in 3T3,C6,Rat Brain,MCF7 cell lysates using NUMB antibody(1:1000 diluted).
Western blot analysis of extracts from Mouse brain tissue using db11426 at 1:1000.
Immunohistochemical analysis of paraffin-embedded human lung cancer using db11426 antibody.