BackgroundThis gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of CtBP1 in A549,MCF-7,U251 cell lysates using CtBP1 antibody(1:1000 diluted).
Western blot analysis of extracts from HepG2 cells using db11279 at 1:1000.
Immunohistochemical analysis of paraffin-embedded human tonsil using db11279 antibody.
Immunofluorescent analysis of HepG2 cells using db11279 antibody (green), and DAPI (blue).