BackgroundThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of GFAP in Rat Brain,Hela cell lysates using GFAP antibody(1:1000 diluted).
Western blot analysis of extracts from Mouse brain tissue using db11248 at 1:10000.
Immunohistochemical analysis of paraffin-embedded human Brain using db11248 antibody.