ASK1 Recombinant Rabbit mAb - diagbio | 戴格生物

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ASK1 Recombinant Rabbit mAb

db11021

Product Name : ASK1 Recombinant Rabbit mAb

Cat.No.: db11021

Synonyms : ASK1; MEKK5; MAPKKK5

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse

Host species : Rabbit

Background Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human ASK1
Gene ID 4217
Swiss Prot Q99683
Synonyms ASK1; MEKK5; MAPKKK5
Reactivity Human, Mouse
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:1000
IHC: 1:50
ICC/IF: 1:20-1:50
FC: 1:20
Calculated MW 155 kDa
Observed MW 155 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of ASK1 in Hela cell lysates using ASK1 antibody(1:1000 diluted).

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