Lamin A/C Recombinant Rabbit mAb - diagbio | 戴格生物

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Lamin A/C Recombinant Rabbit mAb

db11008

Product Name : Lamin A/C Recombinant Rabbit mAb

Cat.No.: db11008

Synonyms : FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B

Application : WB, IHC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Immunogen A synthetic peptide of human Lamin A/C
Gene ID 4000
Swiss Prot P02545
Synonyms FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
Reactivity Human, Mouse, Rat
Application WB, IHC
Recommended dilution WB: 1:2000-1:20000
IHC: 1:100-1:200
Calculated MW 74 kDa
Observed MW 74,63 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Lamin A/C in U251,Lncap,A549 using Lamin A/C antibody(1:1000 diluted)

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