研究领域 Research Field
神经科学 查看所有相关产品
神经发育与神经细胞标志物

Neurodevelopment and nerve cell markers

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神经内分泌

Neuroendocrine

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神经退行性疾病

Neurodegenerative diseases

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神经发育是基于脑发育的分子和细胞活动,中枢神经系统发育从神经嵴的形成开始,逐渐形成神经管。不同级 别的信号会在神经管的不同位置生成差异化的神经上皮微环境,特异的神经上皮祖细胞会引起神经管区域化,并随时间的推移发生增殖、迁移和分化,最终在脑和脊髓内形成独特的生理结构。 神经祖细胞的多能性随着发育与细胞分裂逐步受限,神经元和神经胶质细胞由此产生。神经元作为中枢神经系 统的重要细胞,能够处理电化学信号,其结构通常包含胞体、树突以及轴突。随着神经元的不断迁移,脑皮层 便会由内向外地不断分层,较深的皮层会在浅表层之前形成。 星形胶质细胞与小胶质细胞属于脑中的免疫细胞,前者由神经祖细胞产生,后者源于髓系,二者将迁移到脑中 增殖发育,它们在调节神经元的活动中起着重要的作用。少突胶质细胞来源于神经祖细胞分化,主要功能为产 生髓磷脂并参与髓鞘的形成。髓鞘能通过包裹轴突提升神经元间电信号的传导速度。Schwann细胞的功能与 存在于中枢神经系统的少突胶质细胞相同,它存在于外周神经系统。为了鉴定神经元和神经胶质细胞,众多研究已经发掘出识别这些神经相关细胞的标志物。

神经发育与神经细胞标志物
靶标 产品货号 产品名称 反应种属 应用
BRG1 db3420 BRG1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP,ChIP
db22184 BRG1 Rabbit pAb Human, Mouse WB
db3040 BRG1 Rabbit pAb Human WB,IHC,ICC/IF
db2306 BRG1 Rabbit pAb Human,Mouse,Rat WB
db11111 BRG1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP,ChIP
db6231 BRG1 (6D7) Mouse mAb Human, Mouse WB,ICC/IF,IP
Musashi db1864 Musashi 1/Msi1 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db3005 MSI2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
Nestin db4012 Nestin Rabbit pAb Human IHC,ICC/IF,FC
SOX2 db2678 SOX2 Rabbit pAb Human, Mouse WB,IHC,ICC/IF
db22738 SOX2 Rabbit pAb Human WB,IHC,IP
PAX6 db2269 PAX6 Rabbit pAb Human,Mouse,Rat WB,IHC,FC
db884 PAX6 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db11912 PAX6 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC
db13609 PAX6 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
Doublecortin db212 Doublecortin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db11118 Doublecortin Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
NeuroD1 db4846 NeuroD1 Rabbit pAb Human WB,IHC,ICC/IF
db5249 NeuroD1 Rabbit pAb Human,Mouse,Rat WB,FC,IP
db7 NeuroD1 Rabbit pAb Human,Mouse,Rat WB,IP
TBR1 db5174 TBR1 Rabbit pAb Human,Mouse,Rat WB,IHC
beta III Tubulin db1681 beta III Tubulin Rabbit pAb Human,Mouse,Rat WB
db2961 beta III Tubulin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db3037 beta III Tubulin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db13262 beta III Tubulin Recombinant Rabbit mAb Human,Mouse,Rat WB
db12328 beta III Tubulin Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
NeuN db2833 NeuN Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db20298 NeuN Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db12692 NeuN Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
MAP2 db6438 MAP2 (3B5) Mouse mAb Human,Mouse,Rat IHC-P,ICC/IF
Tau db7399 Tau Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC
db8769 Tau Rabbit pAb Human, Mouse WB,IHC,IP
db1777 Tau Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db13107 Tau Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC
db11940 Tau Recombinant Rabbit mAb Human, Mouse WB,IHC,IP
db12335 Tau Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,IP
Neuro-filament db2351 70 kD Neurofilament Light Rabbit pAb Human,Mouse,Rat WB,IP
db21212 Neurofilament heavy polypeptide Rabbit pAb Human,Mouse,Rat WB,IHC
db3115 Neurofilament heavy polypeptide Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db12729 Neurofilament heavy polypeptide Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
alpha
Internexin
db11442 alpha Internexin Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
db11461 alpha Internexin Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db2556 alpha Internexin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db20777 alpha Internexin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
PSD95 db4413 PSD95 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db22917 PSD95 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
GAP43 db2467 GAP43 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db12045 GAP43 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
beta III Tubulin db1681 beta III Tubulin Rabbit pAb Human,Mouse,Rat WB
db2961 beta III Tubulin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db3037 beta III Tubulin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db13262 beta III Tubulin Recombinant Rabbit mAb Human,Mouse,Rat WB
db12328 beta III Tubulin Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
ChAT db2644 Choline Acetyltransferase Rabbit pAb Human,Mouse,Rat WB,IHC
db3251 Choline Acetyltransferase Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db13806 Choline Acetyltransferase Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
AchE db8205 Acetylcholinesterase Rabbit pAb Mouse,Rat WB,IHC
TH db14958 Tyrosine Hydroxylase Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db1243 Tyrosine Hydroxylase Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
ALDH1A1 db845 ALDH1A1 Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC,IP
db21560 ALDH1A1 Rabbit pAb Human WB,IHC
db12121 ALDH1A1 Recombinant Rabbit mAb Human,Mouse WB,IHC,ICC/IF,FC,IP
FoxA2 db9837 FOXA2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db676 FOXA2 Rabbit pAb Human WB,ICC/IF
db2291 FOXA2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
GABA(A) Receptor db2209 GABA A Receptor alpha 1 Rabbit pAb Human WB,IHC
DARPP32 db20195 DARPP32 Rabbit pAb Human WB,IHC,ICC/IF,IP
db2848 DARPP32 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db12184 DARPP32 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
GAD65 db6127 GAD65 (6D5) Mouse mAb Human,Rat WB
GAD67 db7892 GAD67 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db1321 GAD67 Rabbit pAb Human,Mouse,Rat WB,IP
db11089 GAD67 Recombinant Rabbit mAb Human,Mouse,Rat WB, IP
TPH1 db3640 Tryptophan Hydroxylase Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
Glutaminase db711 Glutaminase Rabbit pAb Human WB,IHC,ICC/IF,FC
db711 Glutaminase Rabbit pAb Human WB,IHC,ICC/IF,FC
Glutamine
Synthetase
db131 Glutamine Synthetase Rabbit pAb Human,Mouse WB,IHC
db929 Glutamine Synthetase Rabbit pAb Human,Mouse,Rat WB,IHC
db11366 Glutamine Synthetase Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC
VGluT1 db5472 VGluT1 Rabbit pAb Human,Mouse,Rat WB
NMDAR db3021 NMDAR1 Rabbit pAb Human,Mouse,Rat WB
db12435 NMDAR1 Recombinant Rabbit mAb Human,Mouse,Rat WB
db339 NMDAR2A Rabbit pAb Mouse,Rat WB
db3385 NMDAR2A Rabbit pAb Human,Mouse,Rat WB
db12123 NMDAR2A Recombinant Rabbit mAb Mouse,Rat WB
GFAP db6433 GFAP (9A2) Mouse mAb Human,Mouse WB,IHC-P,ICC/IF
db1015 GFAP Rabbit pAb Human, Rat WB,IHC,ICC/IF
db3119 GFAP Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db8673 GFAP Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db12000 GFAP Recombinant Rabbit mAb Human,Rat WB,IHC,ICC/IF
db11248 GFAP Recombinant Rabbit mAb Human,Mouse,Rat WB, IHC, IP
NSE db30129 NSE Recombinant Mouse mAb Human IHC
db13423 NSE Recombinant Rabbit mAb Human,Mouse,Rat WB,FC,IP
db6276 NSE (1G7) Mouse mAb Human,Mouse,Rat WB,ELISA
db6277 NSE (1H8) Mouse mAb Human,Mouse,Rat WB,ELISA
db6437 NSE (4C7) Mouse mAb Human,Mouse,Rat WB,ICC/IF,IHC-P
db20544 NSE Rabbit pAb Human, Mouse IHC
db151 NSE Rabbit pAb Human,Mouse,Rat WB,FC,IP
db917 NSE Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
S100B db3755 S100 beta Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db6293 S100B (5G3) Mouse mAb Rat WB
db11749 S100B Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
ALDH1L1 db4074 ALDH1L1 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db11799 ALDH1L1 Recombinant Rabbit mAb Human,Mouse,Rat WB, IHC, IP
CD11b db603 CD11b Rabbit pAb Mouse WB,ICC/IF,FC,IP
db874 CD11b Rabbit pAb Human,Mouse WB,IHC
db21933 CD11b Rabbit pAb Mouse,Rat WB,FC
db9097 CD11b Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db12238 CD11b Recombinant Rabbit mAb Mouse WB,ICC/IF,FC,IP
CD45 db6424 CD45 (8C1) Mouse mAb Human ICC/IF,WB,IHC-P
db6409 CD45 Mouse mAb Human,Mouse WB,IHC-P
CD68 db6426 CD68 (9H5) Mouse mAb Human,Mouse IHC-P,ICC/IF
db3194 CD68 Rabbit pAb Human WB,IHC,ICC/IF
F4/80 db22751 F4/80 Rabbit pAb Human WB,IHC,ICC/IF,FC
Iba1 db315 Iba1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db2608 Iba1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db2881 Iba1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db12419 Iba1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
Olig db22485 Olig1 Rabbit pAb Human,Mouse,Rat WB,FC
db14405 Olig1 Recombinant Rabbit mAb Human,Mouse,Rat WB,FC
db850 Olig2 Rabbit pAb Human,Mouse,Rat WB,IHC
db6196 Olig2 (7A1) Mouse mAb Transfected WB
MBP db3397 Myelin Basic Protein Rabbit pAb Human WB,IHC
db3399 Myelin Basic Protein Rabbit pAb Human,Mouse,Rat WB
db5475 Myelin Basic Protein Rabbit pAb Human,Mouse,Rat WB,IHC
db14893 Myelin Basic Protein Recombinant Rabbit mAb Human WB,IHC
db11374 Myelin Basic Protein Recombinant Rabbit mAb Human,Mouse,Rat WB
db11667 Myelin Basic Protein Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC
SOX10 db1019 SOX10 Rabbit pAb Human IHC
db1462 SOX10 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC
db12273 SOX10 Recombinant Rabbit mAb Human IHC
db12463 SOX10 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC
S100A1 db848 S100 alpha Rabbit pAb Human,Mouse,Rat WB,IHC
db23533 S100 alpha Rabbit pAb Human,Mouse,Rat WB,ICC/IF
神经信号传递

神经信号是一种电信号,其传导速度极快,信号在神经上传递时表现为电位变化,但在胞体间传递时却有不同的介质。神经信号传递是指将动作电位(神经冲动、信号)沿着其轴索进行运送,以及将信号从一个神经元传递至另一神经元或传递至一个效应细胞引发的出的相应的反应。神经元是能处理电化学信号的特殊细胞,最主要的功能是通过突触进行细胞间的信息传递。它的树突和轴突分别承担信号输入和输出的功能。发出信号的神经元称为突触前细胞,而接受信号的神经元则称为突触后细胞,二者之间的胞外间隙称为突触。

突触前细胞中的配体和电压门控离子通道,通过控制离子涌入调控膜电位。阳离子快速涌入细胞会去极化突触前神经元,触发动作电位,通过轴突传播到突触前末端。在电压门控钙通道的作用下,钙离子涌入突触前末端,含有神经递质的突触囊泡会结合突触前膜,释放神经递质到胞外。这些神经递质穿过突触,结合到突触后细胞树突上部的突触后受体,从而完成神经信号传递。整个信号传递过程中,包括G蛋白偶联受体、受体酪氨酸激酶和离子通道等数十种细胞受体将参与其中。这些受体。

靶标 产品货号 产品名称 反应种属 应用
Adenosine A1
Receptor
db8514 Adenosine A1 Receptor Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db11239 Adenosine A1 Receptor Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
P2Y6 db645 P2Y6 Rabbit pAb Human WB,IHC,ICC/IF,IP
db12145 P2Y6 Recombinant Rabbit mAb Human WB,IHC,ICC/IF,IP
P2Y12 db20282 P2Y12 Rabbit pAb Human,Mouse,Rat WB,IP
db12249 P2Y12 Recombinant Rabbit mAb Human,Mouse,Rat WB,IP
P2Y13 db22289 P2Y13 Rabbit pAb Human,Mouse,Rat WB
db12302 P2Y13 Recombinant Rabbit mAb Human,Mouse,Rat WB
Adrenergic
Receptor
db1028 alpha 1a Adrenergic Receptor Rabbit pAb Human,Mouse,Rat WB,IHC,FC
db12890 alpha 1a Adrenergic Receptor Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC
db1583 beta 2 Adrenergic Receptor Rabbit pAb Human,Mouse,Rat WB,IHC,IP
5-HT
Receptor
db4401 5HT2C Receptor Rabbit pAb Human,Mouse,Rat WB
Muscarinic
Acetylcholine
Receptor
db2565 Muscarinic Acetylcholine Receptor 2 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db13920 Muscarinic Acetylcholine Receptor 2 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,IP
Dopamine
Receptor
db3880 Dopamine Receptor D1 Rabbit pAb Human,Mouse,Rat WB
db20410 Dopamine Receptor D3/DRD3 Rabbit pAb Human,Mouse,Rat WB
GABA B
Receptor
db3845 GABA B Receptor 2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
Ephrin
Receptor
db7367 Ephrin receptor A2 Rabbit pAb Mouse, Rat WB,ICC/IF,FC,IP
db20345 Ephrin Receptor B1 Rabbit pAb Human,Mouse,Rat WB,IP
db14170 Ephrin Receptor B1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IP
db8914 Ephrin B2 Rabbit pAb Human,Mouse,Rat WB,ICC/IF
db3874 Ephrin receptor B3 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db22810 Ephrin Receptor B4 Rabbit pAb Human,Mouse WB,IHC
db14113 Ephrin Receptor B4 Recombinant Rabbit mAb Human,Mouse WB,IHC
Trk db4851 TrkA Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db21537 TrkA Rabbit pAb Human,Mouse,Rat WB,IHC
db1802 TrkA Rabbit pAb Human,Mouse,Rat WB,FC,IP
db2266 TrkB Rabbit pAb Human WB,IHC,IP
db3625 TrkB Rabbit pAb Mouse,Rat WB,IHC,IP
db14636 TrkB Recombinant Rabbit mAb Mouse,Rat WB,IHC,IP
Glutamate
Receptor
db558 Glutamate Receptor 1 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db2020 Glutamate receptor 2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11874 Phospho-Glutamate Receptor 1 (AMPA Subtype) (Ser845) Recombinant Rabbit mAb Human,Mouse,Rat WB
NMDAR db3021 NMDAR1 Rabbit pAb Human,Mouse,Rat WB
db12435 NMDAR1 Recombinant Rabbit mAb Human,Mouse,Rat WB
db339 NMDAR2A Rabbit pAb Mouse,Rat WB
db3385 NMDAR2A Rabbit pAb Human,Mouse,Rat WB
db12123 NMDAR2A Recombinant Rabbit mAb Mouse,Rat WB
Transient
Receptor
Potential
Channel
db4665 TRP1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db8461 TRPV5 Rabbit pAb Human,Mouse,Rat WB,IHC,FC,IP
db11189 TRPV5 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC,IP
Calmodulin db2031 Calmodulin 3 Rabbit pAb Human,Mouse,Rat WB,FC,IP
Calreticulin db2680 Calreticulin Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
SNAP25 db21234 SNAP25 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db9076 SNAP25 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db11478 SNAP25 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db14847 SNAP25 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
神经内分泌

神经内分泌主要指神经系统和内分泌系统之间的调控关系,比如神经系统如何调节内分泌系统、内分泌系统如何影响神经功能、神经元的内分泌功能等等。神经内分泌细胞是一种特化的神经元,通过突触接受其他神经元传递的电化学信号,以释放神经激素的方式通过血管或者旁分泌,调节器官的功能。

神经内分泌细胞广泛分布于中枢神经系统及周围血管中,主要通过分泌下丘脑释放激素来发挥作用,影响下丘脑区域的激素调控,下丘脑通过垂体控制生物体内的大部分激素,从而调节睡眠、生殖和压力反应等生命过程。

 

靶标 产品货号 产品名称 反应种属 应用
Growth
Hormone
db4717 Growth Hormone Rabbit pAb Human WB
db7353 Growth Hormone Rabbit pAb Human WB,IHC
db20376 Growth Hormone Rabbit pAb Human WB,IHC,IP
db4717 Growth Hormone Rabbit pAb Human WB
db7353 Growth Hormone Rabbit pAb Human WB,IHC
db20376 Growth Hormone Rabbit pAb Human WB,IHC,IP
Somatostatin
Receptor
db988 Somatostatin Receptor 2 Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db3857 Somatostatin Receptor 3 Rabbit pAb Human WB,FC
db14534 Somatostatin Receptor 3 Recombinant Rabbit mAb Human WB,FC
Estrogen
Receptor
db12490 Estrogen Receptor alpha Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP,ChIP
db8899 Estrogen Receptor alpha Rabbit pAb Human WB,IHC
db95 Estrogen Receptor alpha Rabbit pAb Human WB,IHC,ICC/IF,FC,IP,ChIP
db449 Estrogen Receptor alpha Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP,ChIP
Progesterone
Receptor
db6474 Progesterone Receptor (8H3) Mouse mAb Human,Mouse,Rat IHC-P,IHC-F,ICC/IF
db8429 Progesterone Receptor Rabbit pAb Human,Mouse,Rat WB
db288 Progesterone Receptor Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
POMC db8893 POMC Rabbit pAb Human,Mouse,Rat WB,IHC
db2437 POMC Rabbit pAb Human,Mouse,Rat WB,IHC,IP
Oxytocin db5246 Oxytocin Rabbit pAb Mouse,Rat WB,IHC
Oxytocin Receptor db2464 Oxytocin Receptor Rabbit pAb Human,Mouse,Rat WB
Parathyroid
Hormone
db3095 Parathyroid Hormone Rabbit pAb Human WB,IHC
db3105 Parathyroid Hormone Rabbit pAb Human WB,IHC
db3258 Parathyroid Hormone Rabbit pAb Human WB,IHC
Thyroid Hormone
Receptor
db4065 Thyroid Hormone Receptor alpha Rabbit pAb Human WB
Thyroid
Peroxidase
db20540 Thyroid Peroxidase/TPO Rabbit pAb Human WB,IHC,IP
Thyrotropin db20549 Thyrotropin Subunit beta Rabbit pAb Human WB,IHC
Thyrotropin
Receptor
db2938 TSH Receptor Rabbit pAb Human IHC
神经退行性疾病

神经系统是极其复杂的系统,它对体内生理功能的调节起着主导性作用。在正常生理情况下,神经系统是稳定运作的,但当机体受到某些遗传或环境因素的影响时,神经系统的功能受到干扰可能会出现病变。神经退行性疾病就是由于神经系统中,神经元结构或功能逐渐丧失,而导致的一类神经功能障碍疾病。

帕金森症

又称振颤麻痹,是一种中枢神经系统的慢性疾病。它是由于黑质中多巴胺神经变性,引起多巴胺含量明显下降,胆碱能神经功能相对占优势而引起的疾病。其症状表现为:静止性振颤、运动迟缓、肌肉强直、姿态不稳、四肢抖动,其中四肢抖动在静止时明显,活动时减轻、激动时加重,睡眠时消失。抖动的顺序从一侧上肢开始,再到同侧下肢,再到同侧肢体。患者日常活动和运动均减慢,颜面缺乏表情即面具脸,吞咽困难,致流涎;少动、语音低调,起居翻身困难;行走时,步距缩短,一旦迈步,有“慌张步态”。帕金森是一种慢性疾病,一般不能自行缓解,必须长期服药治疗。

 

靶标 产品货号 产品名称 反应种属 应用
Alpha Synuclein db3346 Alpha-synuclein Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db14600 Alpha-synuclein Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,IP
db21398 Phospho-Alpha-synuclein (Tyr125) Rabbit pAb Human WB,ICC/IF
DJ1 db1214 PARK7/DJ1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db2804 PARK7/DJ1 Rabbit pAb Human WB
db11078 PARK7/DJ1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
Nrf2 db3180 Nrf2 Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC,IP,ChIP
db523 Phospho-Nrf2 (Ser40) Rabbit pAb Human WB,IHC,ICC/IF,FC
db14010 Phospho-Nrf2 (Ser40) Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC
p53 db9894 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db9370 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db488 p53 Rabbit pAb Human WB,ICC/IF
db3246 p53 Rabbit pAb Human WB,IHC,ICC/IF
db14679 p53 Recombinant Rabbit mAb Mouse WB,ICC/IF,FC,IP
db12023 p53 Recombinant Rabbit mAb Human WB,ICC/IF
PINK1 db3331 PINK1 Rabbit pAb Human WB,ICC/IF,IP
PGP9.5 db11099 PGP9.5 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db6161 PGP9.5 (7B8) Mouse mAb Human, Monkey WB,ICC/IF
db6162 PGP9.5 (7B8G5E7) Mouse mAb Human WB,ICC/IF
db1854 PGP9.5 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db2612 PGP9.5 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
阿尔兹海默病(AD)

阿尔兹海默症是一种常见的神经退行性疾病,临床上以记忆障碍、失语、失用、失认、视空间技能损害、执行功能障碍以及人格和行为改变等全面性痴呆为表现特征。是一种起病隐匿的进行性认知和记忆力损害为主的中枢发展的神经系统退行性疾病,同时也是一种中枢神经系统变性病,是大脑变性中最常见的病症。最先出现是健忘,后出现进行性智能减退,反应迟钝,分析、综合、理解、判断能力下降,重复语音和刻板动作。90%的 AD 患者在神经冲动传输过程中缺乏胆碱。乙酰胆碱(Ach)是一种重要的神经递质,参与神经信号的传导,与学习、记忆密切相关。再次,AD 患者的脑神经细胞凋亡率要比正常人的高 40 倍左右,因此神经细胞凋亡可能是中枢神经系统衰退的主要原因之一。

靶标 产品货号 产品名称 反应种属 应用
AKT db5728 AKT Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11977 AKT Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db1727 Phospho-AKT1 (Ser473) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db3626 Phospho-AKT1 (Ser473) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF
db6344 AKT Mouse mAb Human,Mouse,Rat WB,IP
db14851 Phospho-AKT1 (Ser473) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF
alpha-secretase db260 ADAM10 Rabbit pAb Human,Mouse,Rat WB,IP
APP db5393 Amyloid Precursor Protein Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db7700 Amyloid Precursor Protein Rabbit pAb Human WB,IP
db861 Amyloid Precursor Protein Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11190 Amyloid Precursor Protein Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db12240 Amyloid Precursor Protein Recombinant Rabbit mAb Human WB,IP
db12005 Amyloid Precursor Protein Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db21719 Phospho-Amyloid Precursor Protein (Thr743) Rabbit pAb Human,Mouse,Rat WB,ICC/IF,IP
db14545 Phospho-Amyloid Precursor Protein (Thr743) Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,IP
beta-secretase db5038 BACE1 Rabbit pAb Mouse,Rat WB,IHC,IP
db5657 BACE1 Rabbit pAb Human,Mouse,Rat WB,IP
db13283 BACE1 Recombinant Rabbit mAb Mouse,Rat WB,IHC,IP
CDK5 db2767 Cdk5 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db6097 CDK5 (2E8) Mouse mAb Human,Mouse,Rat,Monkey WB,ICC/IF
gamma-secretas db13175 Presenilin 1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db1298 Presenilin 1 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11569 Presenilin 2 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db380 Presenilin 2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db1680 Nicastrin Rabbit pAb Human,Mouse,Rat WB,FC,IP
db2273 Nicastrin Rabbit pAb Human WB,ICC/IF
db14354 Nicastrin Recombinant Rabbit mAb Human,Mouse,Rat WB,FC,IP
db21233 PEN2 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db12942 PEN2 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
GSK3β db6073 GSK3 beta (2E6) Mouse mAb Human,Mouse,Rat WB,ICC/IF,IP,FC
db1715 Phospho-GSK3 beta (Ser9) Rabbit pAb Human WB,IHC,ICC/IF
db13257 Phospho-GSK3 beta (Ser9) Recombinant Rabbit mAb Human WB,IHC,ICC/IF
db2953 GSK3 (alpha/beta) Rabbit pAb Human,Mouse,Rat WB
db14079 GSK3 (alpha/beta) Recombinant Rabbit mAb Human,Mouse,Rat WB
PKC db2373 PKC alpha Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db13040 PKC alpha Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db1662 Phospho-PKC alpha (Thr638) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db11122 Phospho-PKC alpha (Thr638) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
Tau db7399 Tau Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC
db8769 Tau Rabbit pAb Human, Mouse WB,IHC,IP
db1777 Tau Rabbit pAb Human,Mouse,Rat WB,IHC,IP
db13107 Tau Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC
db11940 Tau Recombinant Rabbit mAb Human,Mouse WB,IHC,IP
db12335 Tau Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,IP
db5219 Phospho-Tau (Thr181) Rabbit pAb Human WB,IP
db13902 Phospho-Tau (Thr181) Recombinant Rabbit mAb Human WB,IP
db1765 Phospho-Tau (Ser202) Rabbit pAb Human,Mouse,Rat WB,IP
db13380 Phospho-Tau (Ser202) Recombinant Rabbit mAb Human,Mouse,Rat WB,IP
db1700 Phospho-Tau (Thr231) Rabbit pAb Human,Mouse,Rat WB,IHC,IP
朊病毒疾病

朊病毒疾病是人和动物的一种致死型神经退行性疾病。朊病毒是一个超出经典病毒学和生物学的全新概念,蛋白质在特定条件下发生突变或构型上的变化,由良性变为恶性,即变为具有传染性的侵染颗粒,可引起人和动物脑内神经元空泡变性(即海绵状变形),所以这类病毒引起的疾病被称为传染性海绵状脑病。

朊病毒病都是致死性中枢神经系统的慢性退化性疾病,病理学上的特点是大脑皮层的神经元细胞退化、空泡变性、死亡、小事,最终被星状细胞取代,而造成海绵状态。患者具有痴呆、共济失调、震颤等症状。目前已知的人和动物朊病毒病有以下几种:1.人的库鲁式病;2.克-雅氏病;3.致死性睡眠综合征;4.吉斯综合征,又称脑软化病;5.疯牛病,即牛海绵状脑病;6.传染性紫貂脑病;7.羊瘙痒症,有绵羊瘙痒症和山羊瘙痒症;8.传染性雪貂白质脑病;9.大耳鹿慢性消耗病

靶标 产品货号 产品名称 反应种属 应用
Bip db6046 GRP78 BiP (4F11) Mouse mAb Human,Mouse,Rat WB,ICC/IF,IP
db3831 GRP78 BiP Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC
db2870 GRP78 BiP Rabbit pAb Human,Mouse,Rat WB,IHC
db14659 GRP78 BiP Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC
ERK db758 ERK1/2 Rabbit pAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db11649 ERK1/2 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF,FC,IP
db1717 Phospho-ERK1 (pThr202/pTyr204) / ERK2 (pThr185/pTyr187) Rabbit pAb Human WB,IHC,ICC/IF,FC
Hsp70 db6670 Hsp70 1A (1D9) Mouse mAb Human,Mouse,Rat WB,IHC-P,ICC/IF
PrP db5716 Prion protein PrP Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db12127 Prion Protein Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC