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细胞自噬之AMPK信号通路

AMPK(AMP-activated protein kinase)信号通路是一种细胞内的信号通路,参与细胞代谢的调节,与细胞的能量代谢密切相关。AMPK是一种重要的蛋白激酶,由蛋白激酶激活蛋白激酶(LKB1)激活,能够响应细胞的能量状态和代谢状态,调节细胞的代谢和生长。

(AMPK结构与激活)

AMPK信号通路的主要功能是维持细胞能量平衡,调节葡萄糖和脂肪酸代谢。AMPK活化能够刺激葡萄糖的摄入和运输,促进葡萄糖的利用,同时缺乏能量供应时,AMPK能够促进脂肪酸的氧化,以维持细胞能量平衡。AMPK的活化还能够促进蛋白质的合成,细胞周期的调节,促进细胞的生长和增殖,以维持细胞的稳态。此外,AMPK的活化还与其他相关的信号通路进行调节,如PI3K信号通路、mTOR信号通路、Wnt信号通路等。AMPK的活化可能对治疗糖尿病、肥胖等疾病具有重要的潜在治疗作用。

(AMPK信号通路转导过程)

众多的生长因子,细胞压力改变,细胞运动改变,能量摄取改变等因素均可激活AMPK上游激酶,主要是LKB1,CaMKK,PKA这三种上游激酶;它们的活化能够磷酸化AMPK的T172,AMPK可进一步磷酸化多种下游的转录因子,参与调控糖代谢,脂代谢,细胞增殖等过程。

产品货号 产品名称 反应种属 实验类型
db13549 MAPKAP Kinase 3 Recombinant Rabbit mAb Human WB,FC,IP
db11742 MAPKAP Kinase 2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IP
db3644 Phospho-PKA alpha/beta/gamma (catalytic subunit) (Thr197) Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db2236 PKA gamma (catalytic subunit) Rabbit pAb Human, Mouse, Rat WB,FC,IP
db11883 Phospho-PKA RII alpha (Ser99) Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, IP
db7114 KLKB1 Rabbit pAb Human WB,IHC,IP
db3157 LKB1 Rabbit pAb Human WB,IP
db11726 CaMKII alpha Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC
db11628 CaMKII delta Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC
db14641 PI3K-gamma Recombinant Rabbit mAb Human WB,FC,IP
db8287 PI3K-gamma Rabbit pAb Human WB,FC,IP
db14657 RSK1 p90 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db6263 RSK1 p90 (6B9) Mouse mAb Human, Mouse, Monkey WB,IP
db7433 RSK1 p90 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db2113 RSK1 p90 Rabbit pAb Human, Mouse, Rat WB,IP
db13171 Ras Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,IP
db14105 RAS Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,FC,IP
db1114 TXNIP Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db11977 AKT1/2/3 Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP
db14689 AKT1/2/3 Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
db14851 Phospho-AKT1 (Ser473) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF
db11063 Phospho-AKT1 (Thr450) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,IP
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