AMPK(AMP-activated protein kinase)信号通路是一种细胞内的信号通路,参与细胞代谢的调节,与细胞的能量代谢密切相关。AMPK是一种重要的蛋白激酶,由蛋白激酶激活蛋白激酶(LKB1)激活,能够响应细胞的能量状态和代谢状态,调节细胞的代谢和生长。
(AMPK结构与激活)
AMPK信号通路的主要功能是维持细胞能量平衡,调节葡萄糖和脂肪酸代谢。AMPK活化能够刺激葡萄糖的摄入和运输,促进葡萄糖的利用,同时缺乏能量供应时,AMPK能够促进脂肪酸的氧化,以维持细胞能量平衡。AMPK的活化还能够促进蛋白质的合成,细胞周期的调节,促进细胞的生长和增殖,以维持细胞的稳态。此外,AMPK的活化还与其他相关的信号通路进行调节,如PI3K信号通路、mTOR信号通路、Wnt信号通路等。AMPK的活化可能对治疗糖尿病、肥胖等疾病具有重要的潜在治疗作用。
(AMPK信号通路转导过程)
众多的生长因子,细胞压力改变,细胞运动改变,能量摄取改变等因素均可激活AMPK上游激酶,主要是LKB1,CaMKK,PKA这三种上游激酶;它们的活化能够磷酸化AMPK的T172,AMPK可进一步磷酸化多种下游的转录因子,参与调控糖代谢,脂代谢,细胞增殖等过程。
产品货号 |
产品名称 |
反应种属 |
实验类型 |
db13549 |
MAPKAP Kinase 3 Recombinant Rabbit mAb |
Human |
WB,FC,IP |
db11742 |
MAPKAP Kinase 2 Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,IP |
db3644 |
Phospho-PKA alpha/beta/gamma (catalytic subunit) (Thr197) Rabbit pAb |
Human, Mouse, Rat |
WB,IHC,ICC/IF,IP |
db2236 |
PKA gamma (catalytic subunit) Rabbit pAb |
Human, Mouse, Rat |
WB,FC,IP |
db11883 |
Phospho-PKA RII alpha (Ser99) Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB, IHC, ICC/IF, IP |
db7114 |
KLKB1 Rabbit pAb |
Human |
WB,IHC,IP |
db3157 |
LKB1 Rabbit pAb |
Human |
WB,IP |
db11726 |
CaMKII alpha Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB, IHC, ICC/IF, FC |
db11628 |
CaMKII delta Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB, IHC |
db14641 |
PI3K-gamma Recombinant Rabbit mAb |
Human |
WB,FC,IP |
db8287 |
PI3K-gamma Rabbit pAb |
Human |
WB,FC,IP |
db14657 |
RSK1 p90 Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,IHC,ICC/IF,FC,IP |
db6263 |
RSK1 p90 (6B9) Mouse mAb |
Human, Mouse, Monkey |
WB,IP |
db7433 |
RSK1 p90 Rabbit pAb |
Human, Mouse, Rat |
WB,IHC,ICC/IF,FC,IP |
db2113 |
RSK1 p90 Rabbit pAb |
Human, Mouse, Rat |
WB,IP |
db13171 |
Ras Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,ICC/IF,IP |
db14105 |
RAS Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,ICC/IF,FC,IP |
db1114 |
TXNIP Rabbit pAb |
Human, Mouse, Rat |
WB,IHC,ICC/IF,FC |
db11977 |
AKT1/2/3 Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB, IHC, ICC/IF, FC, IP |
db14689 |
AKT1/2/3 Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,ICC/IF |
db14851 |
Phospho-AKT1 (Ser473) Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,IHC,ICC/IF |
db11063 |
Phospho-AKT1 (Thr450) Recombinant Rabbit mAb |
Human, Mouse, Rat |
WB,IHC,IP |