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GPCR信号通路

发布时间:2024-06-25 02:16:00

GPCR(G蛋白偶联受体)是真核生物中最大、种类最多的膜受体。G蛋白是能够结合三磷酸鸟苷(GTP)和二磷酸鸟苷(GDP)的特殊蛋白质。与GPCR相关的G蛋白是异源三聚体,这意味着它们具有三个不同的亚基:α亚基,β亚基和γ亚基。这些亚基中的两个α和γ通过脂质锚定物附着在质膜上。配体与GPCR的结合会引起受体构象的改变,进而改变并结合并激活G蛋白。然后G蛋白的活性形式从受体表面释放出来,解离成其α和β/γ亚基。然后,两个亚基都将激活其特定的效应子,从而释放第二个信使。这些信使被蛋白激酶识别,从而导致其活化并触发朝向细胞事件的信号级联。受体结合到各种异源三聚体的G蛋白亚型后可利用不同的支架来激活小分子G蛋白/MAPK级联,并可利用至少三种不同类型的酪氨酸激酶。Src家族激酶在β/γ亚单位激活PI3Kγ后聚集。Src家族激酶还可由受体内化、受体酪氨酸激酶交互激活,或含Pyk2或FAK的整合素支架信号转导来聚集。GPCR还可以利用PLCβ来介导PKC和CaMKII的激活,这样就能达到激活或抑制下游MAPK通路的效果。

靶点 产品货号 产品名称 反应种属 应用
CD97 db13169 CD97 Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
db22276 CD97 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
CDC42 db12632 Phospho-RAC1/Cdc42 (Ser71) Recombinant Rabbit mAb Human WB
db22154 Phospho-RAC1/Cdc42 (Ser71) Rabbit pAb Human WB
db14118 CDC42 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db4231 CDC42 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
c-fos db6207 c-Fos (7D6) Mouse mAb Human, Rat, Monkey WB
db4871 c-Fos Rabbit pAb Human, Mouse WB,IHC,ICC/IF,FC,IP
db4635 c-Fos Rabbit pAb Human, Mouse WB,IHC,ICC/IF,IP
db2018 c-Fos Rabbit pAb Human, Mouse, Rat WB,FC
db15652 c-Fos Recombinant Rabbit mAb Human, Mouse, Rat WB,FC
db14998 c-Fos Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,IP
db14952 c-Fos Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,FC,IP
CREB db11133 Phospho-CREB (Ser133) Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP
db6332 CREB (1E9) Mouse mAb Human, Rat WB
db1783 Phospho-CREB (Ser133) Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db13965 CREB Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC
db2906 CREB Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
EPAC 1 db2006 Epac1 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db11196 Epac1 Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC
Frizzled 8 db21902 Frizzled 9 Rabbit pAb Human, Mouse, Rat WB
db5117 Frizzled 8 Rabbit pAb Human, Mouse, Rat WB
db14884 Frizzled 8 Recombinant Rabbit mAb Human, Mouse, Rat WB
db13276 Frizzled 9 Recombinant Rabbit mAb Human, Mouse, Rat WB
JNK db8572 JNK1 Rabbit pAb Human, Mouse, Rat WB
db58 JNK1 Rabbit pAb Human, Mouse, Rat WB
db6223 JNK1 (1A4) Mouse mAb Human, Mouse, Rat WB,ICC/IF
db13511 JNK1 Recombinant Rabbit mAb Human, Mouse, Rat WB
db12544 JNK1 Recombinant Rabbit mAb Human, Mouse, Rat WB
db20141 Phospho-JNK1 (Thr183/Tyr185) Rabbit pAb Human WB,IP
db11220 Phospho-JNK1 (Thr183/Tyr185) Recombinant Rabbit mAb Human WB,IP
NFKB db3141 NF-kB p65 Rabbit pAb Human, Mouse WB,IHC,ICC/IF,FC,IP
db8358 NF-kB p65 Rabbit pAb Human WB,ICC/IF,FC
db6456 NF-kB p65 (3D2) Mouse mAb Human, Mouse, Rat WB,IHC-F,IHC-P,ICC/IF,IP
db6428 NF-kB p65 (5A10) Mouse mAb Human, Mouse, Rat WB,IHC-P,IP
db13524 NF-kB p65 Recombinant Rabbit mAb Human WB,ICC/IF,FC
db11612 NF-KB p65 Recombinant Rabbit mAb Human, Mouse WB, IHC, ICC/IF, IP
db7996 Phospho-NF-kB p65 (Ser536) Rabbit pAb Human, Mouse, Rat WB,IP
db12441 Phospho-NF-kB p65 (Ser536) Recombinant Rabbit mAb Human, Mouse, Rat WB, IP
db9294 NFkB p100 Rabbit pAb Human, Mouse, Rat WB,ICC/IF,IP
db436 NFkB p100 Rabbit pAb Human, Mouse, Rat WB,ICC/IF,FC,IP
db20292 NFkB p100 Rabbit pAb Human, Mouse WB,ICC/IF,IP
db2823 NFkB p105/p50 Rabbit pAb Human, Mouse, Rat WB,IHC
db6209 NFkB p105 (5E3) Mouse mAb Human, Mouse, Rat WB
db12500 NFkB p100 Recombinant Rabbit mAb Human, Mouse WB,ICC/IF,IP
db11265 NFKB p100 Recombinant Rabbit mAb Human, Mouse, Rat WB, ICC/IF, IP
db15969 NFkB p100 Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,FC,IP
db12511 NFkB p105/p50 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC
PAR2 db3066 PAR2 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db15398 PAR2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
Paxillin db20547 Paxillin Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db1638 Paxillin Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db14728 Paxillin Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db12478 Paxillin Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db13963 Phospho-Paxillin (Tyr118) Recombinant Rabbit mAb Human, Mouse, Rat WB
db3855 Phospho-Paxillin (Tyr118) Rabbit pAb Human, Mouse, Rat WB
PKC db8445 PKC beta 2 Rabbit pAb Human, Rat WB,IHC,ICC/IF,FC,IP
db46 PKC beta 1 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db13454 PKC beta 2 Recombinant Rabbit mAb Human, Rat WB,IHC,ICC/IF,FC,IP
db16067 PKC beta 1 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
PYK2 db6398 PYK2 (4B4) Mouse mAb Human WB,IHC-P
db22335 PYK2 Rabbit pAb Human, Rat WB,IHC,IP
db295 PYK2 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF
db12378 PYK2 Recombinant Rabbit mAb Human, Rat WB,IHC,IP
db16002 PYK2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF
RHOA db76 RhoA Rabbit pAb Human, Mouse, Rat WB,ICC/IF,FC
db16061 RhoA Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,FC
ROCK1 db1651 ROCK1 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db4228 ROCK1 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db13063 ROCK1 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db11120 ROCK1 Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP

 

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